When Papa Smurf is mysteriously taken by evil wizards, Razamel and Gargamel, Smurfette leads the Smurfs on a mission into the real world to save him. With the help of new friends, the Smurfs must discover what defines their destiny to save the universe. When Papa Smurf is taken by evil wizards Razamel and Gargamel, Smurfette leads the Smurfs on a mission to the real world to save him.